Category: Technology

Bioorthogonal reactions are a series of chemical reactions that occur in biological environments with high yields, selectivity, efficiency, and no side reactions. These reactions include copper-catalyzed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition, inverse electron demand Diels-Alder (IEDDA) reaction, and more. These bioorthogonal reactions find extensive applications in various fields, including radionuclide conjugate, metabolic engineering, drug…

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Fatty acids are essential for cell survival and function as biological energy substrates, structural components, and signaling molecules. Given their critical role, cells have evolved mechanisms to produce fatty acids from alternative carbon sources, through a process called de novo lipogenesis (DNL). Although DNL is essential for maintaining systemic and intracellular environmental stability, its chronic…

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